Journal article
Gut microbiota of preterm infants supplemented with probiotics: Sub-study of the ProPrems trial
EL Plummer, DM Bulach, GL Murray, SE Jacobs, SN Tabrizi, SM Garland
BMC Microbiology | BMC | Published : 2018
Abstract
Background: The ProPrems trial, a multi-center, double-blind, placebo-controlled randomized trial, previously reported a 54% reduction in necrotizing enterocolitis (NEC) of Bell stage 2 or more from 4.4 to 2.0% in 1099 infants born before 32 completed weeks' gestation and weighing < 1500 g, receiving probiotic supplementation (with Bifidobacterium longum subsp. infantis BB-02, Streptococcus thermophilus TH-4 and Bifidobacterium animalis subsp. lactis BB-12). This sub-study investigated the effect of probiotic supplementation on the gut microbiota in a cohort of very preterm infants in ProPrems. Results: Bifidobacterium was found in higher abundance in infants who received the probiotics (AOR..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Supported by the National Health and Research Medical Council of Australia (project grant 454629), The Royal Women's Hospital Foundation, Melbourne, Australia, and The Angior Family Foundation, Melbourne, Australia. ELP received a bursary scholarship from Victorian Life Science Computation Initiative. Solgar, USA supplied the probiotic combination "ABC Dophilus Powder for Infants" at cost, but did not provide the study with support of any kind. The funders had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. The authors have no other financial relationships relevant to this article to disclose.